Ancient Genomes from Eastern Kazakhstan Unveil the Dynamic Genetic Legacy of Inner Eurasian Hunter-Gatherers
2025年10月15日
Guangming Daily Interprets Baligang Ancient DNA: A 5,000-Year-Old Patrilineal Clan and North–South Cultural Fusion
2025年10月21日1.1 Million STRs Across 7,876 Genomes Illuminate High-Altitude Adaptation on the Qinghai-Tibet Plateau
A team has analyzed more than 1.1 million short tandem repeat (STR) loci across 7,876 whole-genome samples—including 3,808 newly sequenced individuals related to Tibeto-Burman speakers—covering the Qinghai-Xizang Plateau and adjacent regions. The study appears in Science Advances.
Most prior work on high-altitude adaptation has focused on single-nucleotide variation, whereas STRs—numerous, rapidly mutating repeats—can reveal more recent evolutionary and adaptive signals.
The large STR dataset offers fresh insight into the genetic basis of high-altitude adaptation, contrasting plateau populations with lowland neighbors at the STR level and linking these differences to adaptive traits. By combining Tibeto-Burman samples with existing whole-genome data, the work adds repeat-sequence-level evidence for how people settled and adapted to the plateau’s extreme hypoxia.
